Grewia asiatica Linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: Fabrication,characterization and anthelmintic evaluation

Abstract

The current study was planned to formulate the Grewia asiatica Linn. root extract loaded herbal formulation and evaluated its potential for in vitro anthelmintic activity. The root extract of Grewia asiatica Linn. was standardized by HPTLC using quercetin and naringenin, as a marker compound. The extract was formulated into a novel microparticulate and nanosuspension dosage form based on the Eudragit S100. The prepared dosage forms were characterized by particle size, morphology, and in vitro release behavior. Further, the comparative evaluation of dosage form revealed the presence of higher in vitro anthelmintic activity in nanosuspension as compared to conventional suspension and microparticulate dosage form.