Integrated network pharmacology and in-silico approaches to decipher the pharmacological mechanism of Selaginella tamariscina in the treatment of non-small cell lung cancer

Abstract

Non-small cell lung cancer (NSCLC) is a major pathological type of lung cancer and accounts for more than 80% of all cases. In healthcare management, it is challenging to understand the mechanism of NSCLC due to diverse spectra and the limited number of reported data. Selaginella tamariscina is an evergreen perennial plant, hermaphrodite, and used to treat numerous diseases, including NSCLC. In vitro research revealed the therapeutic importance of S. tamariscina in contrast to NSCLC, but the molecular mechanism is still unclear. In the present study, a network pharmacology technique was employed to uncover the active ingredients, their potential targets, and signaling pathways in S. tamariscina for the treatment of NSCLC.